Factors influencing outcome and incidence of long-term complications in children who underwent autologous stem cell transplantation for acute myeloid leukemia in first complete remission
Identifieur interne : 00B190 ( Main/Exploration ); précédent : 00B189; suivant : 00B191Factors influencing outcome and incidence of long-term complications in children who underwent autologous stem cell transplantation for acute myeloid leukemia in first complete remission
Auteurs : Franco Locatelli [Italie, France, Espagne, Israël, Australie, Belgique] ; Myriam Labopin ; Juan Ortega Giovanna Meloni ; Giorgio Dini ; Chiara Messina ; Isaac Yaniv ; Franca Fagioli ; Victoria Castel ; Peter J. Shaw ; Augustin Ferrant ; Andrea Pession ; Gerard Socie ; Francesco FrassoniSource :
- Blood [ 0006-4971 ] ; 2003.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Enfant, Cellule souche, Santé publique.
English descriptors
- KwdEn :
Abstract
To evaluate factors influencing outcome and incidence of long-term complications, we analyzed, in a retrospective, multicenter study, 387 children who underwent autologous hematopoietic stem cell transplantation (HSCT) for acute myeloid leukemia (AML) in first complete remission (CR). Median follow-up time from transplantation was 60 months. Transplantation of bone marrow cells was performed in 318 children, whereas in 60 patients peripheral blood progenitor cells (PBPCs) were used. In multivariate analysis, we investigated the variables influencing probability of hematopoietic recovery, transplantation-related mortality (TRM), relapse, and leukemia-free survival (LFS). We found that use of PBPCs as stem cell sources and use of BCNU (N,N-bis[2-chloroethyl]-N-nitrosourea), amsacrine, VP-16, and cytosine arabinoside (BAVC) as a preparative regimen were associated with faster neutrophil recovery. Infusion of PBPCs, young age of patients, use of BAVCs, and absence of marrow purging predicted an accelerated platelet reconstitution. The 5-year Kaplan-Meler estimates of TRM, relapse, and LFS were 3% ± 1%, 39% ± 3% and 60% ± 3%, respectively. Relapse probability was increased in children given the BAVC regimen, and it was decreased after In vitro purging of hematopoietic progenitors and in children with a French-American-British classification of M3 and a time Interval of 170 days or more between CR and HSCT. These 2 latter variables favorably Influenced the probability of LFS, which was, by contrast, reduced with the BAVC regimen. Thirty-three percent of patients surviving more than 18 months experienced at least one late sequela; use of total body irradiation was the only predictive factor. The results obtained in this analysis can be of help in designing prospective studies of autologous HSCT in children with AML in first CR.
Affiliations:
- Australie, Belgique, Espagne, France, Israël, Italie
- Catalogne, Latium, Nouvelle-Galles du Sud, Région de Bruxelles-Capitale, Vénétie, Émilie-Romagne, Île-de-France
- Barcelone, Bologne, Bruxelles, Padoue, Paris, Rome, Sydney
- Université de Bologne, Université de Padoue
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 005302
- to stream PascalFrancis, to step Curation: 000E24
- to stream PascalFrancis, to step Checkpoint: 004F72
- to stream Main, to step Merge: 00BF57
- to stream Main, to step Curation: 00B190
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Factors influencing outcome and incidence of long-term complications in children who underwent autologous stem cell transplantation for acute myeloid leukemia in first complete remission</title><author><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Oncoematologia Pediatrica, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Université di Pavia</s1><s3>ITA</s3></inist:fA14><country>Italie</country><wicri:noRegion>Oncoematologia Pediatrica, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Université di Pavia</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>European Data Management Office</s1><s2>Paris</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Hospital Matemo Infantil, Vall d'Hebron</s1><s2>Barcelona</s2><s3>ESP</s3></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Dipartimento di Biotecnologie Cellulari ed Ematologia, Université La Sapienza</s1><s2>Roma</s2><s3>ITA</s3></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Dipartimento di Ematologia ed Oncologia, Istituto G. Gaslini</s1><s2>Genova</s2><s3>ITA</s3></inist:fA14><country>Italie</country><wicri:noRegion>Genova</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Clinica Pediatrica, Università di Padova</s1><s3>ITA</s3></inist:fA14><country>Italie</country><placeName><settlement type="city">Padoue</settlement><region type="region" nuts="2">Vénétie</region></placeName><orgName type="university">Université de Padoue</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Bone Marrow Transplantation Unit, Schneider Children's Medical Center of Israel</s1><s2>Petach-Tikva</s2><s3>ISR</s3></inist:fA14><country>Israël</country><wicri:noRegion>Petach-Tikva</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Clinica Pediatrica, Università di Torino</s1><s3>ITA</s3></inist:fA14><country>Italie</country><wicri:noRegion>Clinica Pediatrica, Università di Torino</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Hospital Infantil La Fe</s1><s2>Valencia</s2><s3>ESP</s3></inist:fA14><country>Espagne</country><wicri:noRegion>Hospital Infantil La Fe</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Oncology Unit, Children Hospital at Westmead</s1><s2>Sydney</s2><s3>AUS</s3></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Cliniques Universitaires St Luc</s1><s2>Brussels</s2><s3>BEL</s3></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="12"><s1>Clinica Pediatrica, Università di Bologna</s1><s3>ITA</s3></inist:fA14><country>Italie</country><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName><orgName type="university">Université de Bologne</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Hematology, Bone Marrow Transplantation Unit, Hôpital Saint-Louis</s1><s2>Paris</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Divisione di Ematologia Il, Ospedale San Martino</s1><s2>Genova</s2><s3>ITA</s3></inist:fA14><country>Italie</country><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Labopin, Myriam" sort="Labopin, Myriam" uniqKey="Labopin M" first="Myriam" last="Labopin">Myriam Labopin</name></author><author><name sortKey="Giovanna Meloni, Juan Ortega" sort="Giovanna Meloni, Juan Ortega" uniqKey="Giovanna Meloni J" first="Juan Ortega" last="Giovanna Meloni">Juan Ortega Giovanna Meloni</name></author><author><name sortKey="Dini, Giorgio" sort="Dini, Giorgio" uniqKey="Dini G" first="Giorgio" last="Dini">Giorgio Dini</name></author><author><name sortKey="Messina, Chiara" sort="Messina, Chiara" uniqKey="Messina C" first="Chiara" last="Messina">Chiara Messina</name></author><author><name sortKey="Yaniv, Isaac" sort="Yaniv, Isaac" uniqKey="Yaniv I" first="Isaac" last="Yaniv">Isaac Yaniv</name></author><author><name sortKey="Fagioli, Franca" sort="Fagioli, Franca" uniqKey="Fagioli F" first="Franca" last="Fagioli">Franca Fagioli</name></author><author><name sortKey="Castel, Victoria" sort="Castel, Victoria" uniqKey="Castel V" first="Victoria" last="Castel">Victoria Castel</name></author><author><name sortKey="Shaw, Peter J" sort="Shaw, Peter J" uniqKey="Shaw P" first="Peter J." last="Shaw">Peter J. Shaw</name></author><author><name sortKey="Ferrant, Augustin" sort="Ferrant, Augustin" uniqKey="Ferrant A" first="Augustin" last="Ferrant">Augustin Ferrant</name></author><author><name sortKey="Pession, Andrea" sort="Pession, Andrea" uniqKey="Pession A" first="Andrea" last="Pession">Andrea Pession</name></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gerard" last="Socie">Gerard Socie</name></author><author><name sortKey="Frassoni, Francesco" sort="Frassoni, Francesco" uniqKey="Frassoni F" first="Francesco" last="Frassoni">Francesco Frassoni</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">03-0346488</idno><date when="2003">2003</date><idno type="stanalyst">PASCAL 03-0346488 INIST</idno><idno type="RBID">Pascal:03-0346488</idno><idno type="wicri:Area/PascalFrancis/Corpus">005302</idno><idno type="wicri:Area/PascalFrancis/Curation">000E24</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">004F72</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">004F72</idno><idno type="wicri:doubleKey">0006-4971:2003:Locatelli F:factors:influencing:outcome</idno><idno type="wicri:Area/Main/Merge">00BF57</idno><idno type="wicri:Area/Main/Curation">00B190</idno><idno type="wicri:Area/Main/Exploration">00B190</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Factors influencing outcome and incidence of long-term complications in children who underwent autologous stem cell transplantation for acute myeloid leukemia in first complete remission</title><author><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Oncoematologia Pediatrica, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Université di Pavia</s1><s3>ITA</s3></inist:fA14><country>Italie</country><wicri:noRegion>Oncoematologia Pediatrica, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Université di Pavia</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>European Data Management Office</s1><s2>Paris</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Hospital Matemo Infantil, Vall d'Hebron</s1><s2>Barcelona</s2><s3>ESP</s3></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Dipartimento di Biotecnologie Cellulari ed Ematologia, Université La Sapienza</s1><s2>Roma</s2><s3>ITA</s3></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Dipartimento di Ematologia ed Oncologia, Istituto G. Gaslini</s1><s2>Genova</s2><s3>ITA</s3></inist:fA14><country>Italie</country><wicri:noRegion>Genova</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Clinica Pediatrica, Università di Padova</s1><s3>ITA</s3></inist:fA14><country>Italie</country><placeName><settlement type="city">Padoue</settlement><region type="region" nuts="2">Vénétie</region></placeName><orgName type="university">Université de Padoue</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Bone Marrow Transplantation Unit, Schneider Children's Medical Center of Israel</s1><s2>Petach-Tikva</s2><s3>ISR</s3></inist:fA14><country>Israël</country><wicri:noRegion>Petach-Tikva</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Clinica Pediatrica, Università di Torino</s1><s3>ITA</s3></inist:fA14><country>Italie</country><wicri:noRegion>Clinica Pediatrica, Università di Torino</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Hospital Infantil La Fe</s1><s2>Valencia</s2><s3>ESP</s3></inist:fA14><country>Espagne</country><wicri:noRegion>Hospital Infantil La Fe</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Oncology Unit, Children Hospital at Westmead</s1><s2>Sydney</s2><s3>AUS</s3></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Cliniques Universitaires St Luc</s1><s2>Brussels</s2><s3>BEL</s3></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="12"><s1>Clinica Pediatrica, Università di Bologna</s1><s3>ITA</s3></inist:fA14><country>Italie</country><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName><orgName type="university">Université de Bologne</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Hematology, Bone Marrow Transplantation Unit, Hôpital Saint-Louis</s1><s2>Paris</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Divisione di Ematologia Il, Ospedale San Martino</s1><s2>Genova</s2><s3>ITA</s3></inist:fA14><country>Italie</country><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Labopin, Myriam" sort="Labopin, Myriam" uniqKey="Labopin M" first="Myriam" last="Labopin">Myriam Labopin</name></author><author><name sortKey="Giovanna Meloni, Juan Ortega" sort="Giovanna Meloni, Juan Ortega" uniqKey="Giovanna Meloni J" first="Juan Ortega" last="Giovanna Meloni">Juan Ortega Giovanna Meloni</name></author><author><name sortKey="Dini, Giorgio" sort="Dini, Giorgio" uniqKey="Dini G" first="Giorgio" last="Dini">Giorgio Dini</name></author><author><name sortKey="Messina, Chiara" sort="Messina, Chiara" uniqKey="Messina C" first="Chiara" last="Messina">Chiara Messina</name></author><author><name sortKey="Yaniv, Isaac" sort="Yaniv, Isaac" uniqKey="Yaniv I" first="Isaac" last="Yaniv">Isaac Yaniv</name></author><author><name sortKey="Fagioli, Franca" sort="Fagioli, Franca" uniqKey="Fagioli F" first="Franca" last="Fagioli">Franca Fagioli</name></author><author><name sortKey="Castel, Victoria" sort="Castel, Victoria" uniqKey="Castel V" first="Victoria" last="Castel">Victoria Castel</name></author><author><name sortKey="Shaw, Peter J" sort="Shaw, Peter J" uniqKey="Shaw P" first="Peter J." last="Shaw">Peter J. Shaw</name></author><author><name sortKey="Ferrant, Augustin" sort="Ferrant, Augustin" uniqKey="Ferrant A" first="Augustin" last="Ferrant">Augustin Ferrant</name></author><author><name sortKey="Pession, Andrea" sort="Pession, Andrea" uniqKey="Pession A" first="Andrea" last="Pession">Andrea Pession</name></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gerard" last="Socie">Gerard Socie</name></author><author><name sortKey="Frassoni, Francesco" sort="Frassoni, Francesco" uniqKey="Frassoni F" first="Francesco" last="Frassoni">Francesco Frassoni</name></author></analytic><series><title level="j" type="main">Blood</title><title level="j" type="abbreviated">Blood</title><idno type="ISSN">0006-4971</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Blood</title><title level="j" type="abbreviated">Blood</title><idno type="ISSN">0006-4971</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute myelocytic leukemia</term><term>Autograft</term><term>Child</term><term>Complication</term><term>Europe</term><term>Follow up study</term><term>Graft</term><term>Hematopoietic cell</term><term>Incidence</term><term>Long term</term><term>Multicenter study</term><term>Prognosis</term><term>Public health</term><term>Remission</term><term>Stem cell</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Autogreffe</term><term>Greffe</term><term>Leucémie myéloblastique</term><term>Etude longitudinale</term><term>Europe</term><term>Pronostic</term><term>Incidence</term><term>Long terme</term><term>Complication</term><term>Etude multicentrique</term><term>Enfant</term><term>Cellule hématopoïétique</term><term>Cellule souche</term><term>Rémission</term><term>Santé publique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term><term>Cellule souche</term><term>Santé publique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate factors influencing outcome and incidence of long-term complications, we analyzed, in a retrospective, multicenter study, 387 children who underwent autologous hematopoietic stem cell transplantation (HSCT) for acute myeloid leukemia (AML) in first complete remission (CR). Median follow-up time from transplantation was 60 months. Transplantation of bone marrow cells was performed in 318 children, whereas in 60 patients peripheral blood progenitor cells (PBPCs) were used. In multivariate analysis, we investigated the variables influencing probability of hematopoietic recovery, transplantation-related mortality (TRM), relapse, and leukemia-free survival (LFS). We found that use of PBPCs as stem cell sources and use of BCNU (N,N-bis[2-chloroethyl]-N-nitrosourea), amsacrine, VP-16, and cytosine arabinoside (BAVC) as a preparative regimen were associated with faster neutrophil recovery. Infusion of PBPCs, young age of patients, use of BAVCs, and absence of marrow purging predicted an accelerated platelet reconstitution. The 5-year Kaplan-Meler estimates of TRM, relapse, and LFS were 3% ± 1%, 39% ± 3% and 60% ± 3%, respectively. Relapse probability was increased in children given the BAVC regimen, and it was decreased after In vitro purging of hematopoietic progenitors and in children with a French-American-British classification of M3 and a time Interval of 170 days or more between CR and HSCT. These 2 latter variables favorably Influenced the probability of LFS, which was, by contrast, reduced with the BAVC regimen. Thirty-three percent of patients surviving more than 18 months experienced at least one late sequela; use of total body irradiation was the only predictive factor. The results obtained in this analysis can be of help in designing prospective studies of autologous HSCT in children with AML in first CR.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Espagne</li><li>France</li><li>Israël</li><li>Italie</li></country><region><li>Catalogne</li><li>Latium</li><li>Nouvelle-Galles du Sud</li><li>Région de Bruxelles-Capitale</li><li>Vénétie</li><li>Émilie-Romagne</li><li>Île-de-France</li></region><settlement><li>Barcelone</li><li>Bologne</li><li>Bruxelles</li><li>Padoue</li><li>Paris</li><li>Rome</li><li>Sydney</li></settlement><orgName><li>Université de Bologne</li><li>Université de Padoue</li></orgName></list><tree><noCountry><name sortKey="Castel, Victoria" sort="Castel, Victoria" uniqKey="Castel V" first="Victoria" last="Castel">Victoria Castel</name><name sortKey="Dini, Giorgio" sort="Dini, Giorgio" uniqKey="Dini G" first="Giorgio" last="Dini">Giorgio Dini</name><name sortKey="Fagioli, Franca" sort="Fagioli, Franca" uniqKey="Fagioli F" first="Franca" last="Fagioli">Franca Fagioli</name><name sortKey="Ferrant, Augustin" sort="Ferrant, Augustin" uniqKey="Ferrant A" first="Augustin" last="Ferrant">Augustin Ferrant</name><name sortKey="Frassoni, Francesco" sort="Frassoni, Francesco" uniqKey="Frassoni F" first="Francesco" last="Frassoni">Francesco Frassoni</name><name sortKey="Giovanna Meloni, Juan Ortega" sort="Giovanna Meloni, Juan Ortega" uniqKey="Giovanna Meloni J" first="Juan Ortega" last="Giovanna Meloni">Juan Ortega Giovanna Meloni</name><name sortKey="Labopin, Myriam" sort="Labopin, Myriam" uniqKey="Labopin M" first="Myriam" last="Labopin">Myriam Labopin</name><name sortKey="Messina, Chiara" sort="Messina, Chiara" uniqKey="Messina C" first="Chiara" last="Messina">Chiara Messina</name><name sortKey="Pession, Andrea" sort="Pession, Andrea" uniqKey="Pession A" first="Andrea" last="Pession">Andrea Pession</name><name sortKey="Shaw, Peter J" sort="Shaw, Peter J" uniqKey="Shaw P" first="Peter J." last="Shaw">Peter J. Shaw</name><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gerard" last="Socie">Gerard Socie</name><name sortKey="Yaniv, Isaac" sort="Yaniv, Isaac" uniqKey="Yaniv I" first="Isaac" last="Yaniv">Isaac Yaniv</name></noCountry><country name="Italie"><noRegion><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name></noRegion><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name></country><country name="France"><region name="Île-de-France"><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name></region><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name></region><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name></country><country name="Israël"><noRegion><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name></region></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00B190 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00B190 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:03-0346488
|texte= Factors influencing outcome and incidence of long-term complications in children who underwent autologous stem cell transplantation for acute myeloid leukemia in first complete remission
}}
| This area was generated with Dilib version V0.6.33. |  |